Journal of Prosthetic Dentistry
Volume 103, Issue 6 , Pages 380-383 , June 2010

Hyperzincemia from ingestion of denture adhesives

  • Arzu Tezvergil-Mutluay, DDS, PhD

      Affiliations

    • Adjunct Professor, Department of Prosthetic Dentistry, Institute of Dentistry, University of Turku, Turku, Finland
    • ,
  • Ricardo M. Carvalho, DDS, PhD

      Affiliations

    • Associate Professor, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil
    • ,
  • David H. Pashley, DMD, PhD

      Affiliations

    • Regents' Professor, Emeritus, Department of Oral Biology, School of Dentistry, Medical College of Georgia, Augusta, Ga
    • Corresponding Author InformationCorresponding author: Dr David H. Pashley, School of Dentistry, Medical College of Georgia, Department of Oral Biology, 1120 15th St, CL-2112, Augusta, GA, 30912-1129, Fax: 706-721-6252

References 

  1. Shah NB, Gounaris MC, Holeva KT, inventors; Richardson-Vicks, Inc, assignee. Denture stabilizing zinc and strontium salts of AVE/MA copolymer. US patent 4 758 630. July 19, 1988.
  2. Al RH , Dahl JE , Morisbak E , Polyzois GL . Irritation and cytotoxic potential of denture adhesives . Gerodontology . 2005;22:177–183
  3. Nations SP , Boyer PJ , Love LA , Burritt MF , Butz JA , Wolfe GI , et al.   Denture cream: an unusual source of excess zinc, leading to hypocupremia and neurologic disease . Neurology . 2008;71:639–643
  4. Chen H, Lamer TJ, Rho RH, Marshall KA, Sitzman BT, Ghazi SM, et al. Contemporary management of neuropathic pain for the primary care physician . Mayo Clin Proc . 2004;79:1533–1545
  5. Kumar N , McEvoy KM , Ahlskog JE . Myelopathy due to copper deficiency following gastrointestinal surgery . Arch Neurol . 2003;60:1782–1785
  6. Kumar N , Gross JB , Ahlskog JE . Myelopathy due to copper deficiency . Neurology . 2003;61:273–274
  7. Kumar N , Gross JB , Ahlskog JE . Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration . Neurology . 2004;63:33–39
  8. Kumar N , Crum B , Petersen RC , Vernino SA , Ahlskog JE . Copper deficiency myelopathy . Arch Neurol . 2004;61:762–766
  9. Kumar N . Copper deficiency myelopathy (human swayback) . Mayo Clin Proc . 2006;81:1371–1384
  10. Brewer GJ , Schoomaker EB , Leichtman DA , Kruckleberg WC , Brewer LF , Myers N . The uses of pharmacologic doses of zinc in the treatment of sickle cell anemia . In:  Brewer GJ ,  Prasad AS editor. Zinc metabolism: current aspects in health and disease . New York: Allan R. Liss, Inc.; 1977;p. 241–258
  11. Prasad AS , Brewer GJ , Schoomaker EB , Rabbani P . Hypocupremia induced by zinc therapy in adults . JAMA . 1978;240:2166–2168
  12. Hoffman HN , Phyliky RL , Fleming CR . Zinc-induced copper deficiency . Gastroenterology . 1988;94:508–512
  13. Broun ER , Greist A , Tricot G , Hoffman R . Excessive zinc ingestion. A reversible cause of sideroblastic anemia and bone marrow depression . JAMA . 1990;264:1441–1443
  14. Gyroffy EJ , Chan H . Copper deficiency and microcytic anemia resulting from prolonged ingestion of over-the-counter zinc . Am J Gastroenterol . 1992;87:1054–1055
  15. Prodan CI , Holland NR , Wisdom PJ , Burstein SA , Bottomley SS . CNS demyelination associated with copper deficiency and hyperzincemia . Neurology . 2002;59:1453–1456
  16. Hedera P , Fink JK , Bockenstedt PL , Brewer GJ . Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin: further support for existence of a new zinc overload syndrome . Arch Neurol . 2003;60:1303–1306
  17. Hedera P , Peltier A , Fink JK , Wilcock S , London Z , Brewer GJ . Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin. II. The denture cream is a primary source of excessive zinc . Neurotoxicology . 2009;30:996–999
  18. Yuzbasiyan-Gurkan V , Grider A , Nostrant T , Cousins RJ , Brewer GJ . Treatment of Wilson's disease with zinc: X. Intestinal metallothionein induction . J Lab Clin Med . 1992;120:380–386
  19. Hedera P , Brewer GJ . Letter to the Editor. Reply. Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown source: further support for existence of a new zinc overload syndrome . Arch Neurol . 2004;61:604–605 author reply 605
  20. Spinazzi M , Armani M . Letter to the Editor. Reply. Denture cream: an unusual source of excess zinc, leading to hypocupremia and neurologic disease . Neurology . 2009;73:76
  21. Brewer GJ , Dick RD , Johnson VD , Brunberg JA , Kluin KJ , Fink JK . Treatment of Wilson's disease with zinc: XV long term follow-up studies . J Lab Clin Med . 1998;132:264–278
  22. Roberts EA , Schilsky ML , American Association for Study of Liver Disearses (AASLD)  . Diagnosis and treatment of Wilson disease: An update . Hepatology . 2008;47:2089–2111
  23. Brewer GJ . Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment . CNS Drugs . 2005;19:185–192

PII: S0022-3913(10)60081-9

doi: 10.1016/S0022-3913(10)60081-9

Journal of Prosthetic Dentistry
Volume 103, Issue 6 , Pages 380-383 , June 2010

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