Abstract
Statement of problem
Various factors are responsible for sleep bruxism; however, whether the dopaminergic
agonist group of drugs is effective in the treatment of sleep bruxism is unclear.
Purpose
The purpose of this systematic review was to evaluate the effect of the dopaminergic
agonist group of drugs in controlling sleep bruxism in comparison with no treatment
or placebo-controlled treatment.
Material and methods
Two electronic databases, PubMed and Cochrane Central, were searched by using the
keywords bruxism, sleep bruxism, dopamine, and dopamine agonist. After screening titles
and abstracts, only those articles which met predefined inclusion criteria were selected
for full-text assessment. Clinical trials using the dopaminergic agonist group of
drugs as a treatment approach to sleep bruxism were included.
Results
The literature search yielded a total of 64 articles from the 2 electronic databases
(PubMed, 53; Cochrane Central, 11). After removal of the duplicates (n=8), the initial
screening of titles and abstracts was performed by 2 independent reviewers, removing
46 articles. A total of 10 articles were selected for full-text reading, and 4 studies
were included for qualitative analysis.
Conclusions
Levodopa (L-DOPA) and Bromocriptine showed decrease in root mean square value in electromyography
per bruxism burst (P<.001) and 20% to 30% reduction of bruxism episodes during sleep in 2 different studies.
However, treatment with bromocriptine led to conflicting result in another study in
terms of frequency of bruxism episodes and amplitude of muscle contractions in electromyography
(EMG). Bruxism bursts and episodes were also not significantly improved with another
dopaminergic agonist group of drugs, Pramipexole (P>.001). Based on the limited evidence and conflicting results, significant conclusions
cannot be generated, and further studies are required.
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Article info
Publication history
Published online: January 14, 2021
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© 2020 by the Editorial Council for the Journal of Prosthetic Dentistry.
