Abstract
Undifferentiated pleomorphic sarcoma is a high-grade soft-tissue malignant tumor that
is rare in the head and neck region. A 74-year-old woman displayed a large nodular
lesion in the maxillary alveolar mucosa, which was initially identified as denture-related
fibrous hyperplasia. Although her prosthodontist has adjusted the maxillary complete
denture to relieve pressure on the lesion, it increased in size over time. Computed
tomography images of the maxillary sinus showed an extensive destructive lesion. A
biopsy was performed, and microscopic examination revealed a poorly differentiated
malignancy with numerous spindle cells. Immunohistochemistry reactions were negative
for CD45, CD30, CD68, CD34, cytokeratin, S100, desmin, and smooth muscle actin. These
findings led to the diagnosis of an undifferentiated pleomorphic sarcoma of the maxillary
sinus.
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Article info
Publication history
Published online: April 16, 2021
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© 2021 by the Editorial Council for the Journal of Prosthetic Dentistry.
