Abstract
Statement of problem
Denture adhesives are widely used products, but limited evidence regarding their toxicity
is available.
Purpose
The purpose of this scoping review was to map the existing literature on the toxic
potential of denture adhesives.
Material and methods
This scoping review was structured based on the 5-step methodology proposed by Arksey
and O’Malley and The Joanna Briggs Institute Manual for Evidence Synthesis and followed
the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for
Scoping Reviews. The methods were registered on the Open Science Framework (<osf.io/nqryt>).
The following research question was formulated: Are there any toxic effects related
to the use of denture adhesives? The electronic literature search was performed independently
by 2 authors in the following databases: PubMed/MEDLINE, Scopus, Web of Science, and
the Cochrane Library. The inclusion criteria were in vitro and clinical studies; studies
that evaluated the cytotoxic properties of denture adhesives as local or systemic
implications; and studies published in English.
Results
The search conducted in October 2020 provided 1099 articles. In total, 33 studies
were included, 14 in vitro and 19 clinical studies. Commercially available denture
adhesives have a dose-dependent cytotoxic effect on fibroblasts and keratinocytes,
with poor cell recovery noted in older human fibroblasts. Patients presented different
levels of neurologic or hematological alterations associated with the excessive use
of denture adhesives.
Conclusions
Most commercially available denture adhesives have a dose-dependent cytotoxic effect,
and the use of well-adapted removable dental prostheses, proper patient follow-ups,
and correct instructions for their use when indicated should be a priority.
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Article info
Publication history
Published online: April 19, 2021
Footnotes
Supported by the Departments of Oral Rehabilitation, Faculty of Dentistry, University of Pernambuco, Recife, Brazil and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil, partially supported the study with a scholarship. Financing Code 001.
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© 2021 by the Editorial Council for the Journal of Prosthetic Dentistry.
