Abstract
Statement of problem
Evidence for the efficacy and safety of natural products for the treatment of denture
stomatitis is lacking.
Purpose
The purpose of this systematic review was to answer the question “Are topical natural
substances effective and safe compared with conventional antifungals in the treatment
of denture stomatitis?”
Material and methods
A structured search in 11 databases, including non-peer-reviewed, was undertaken.
Two authors independently selected the studies, extracted the data, assessed the study
quality, and graded the evidence, with disagreement resolved with a third reviewer.
Data were evaluated descriptively by following Synthesis Without Meta-analysis (SWiM)
reporting items. This study was registered at the International Prospective Register
of Systematic Reviews (PROSPERO), number CRD42020216213.
Results
After the removal of duplicates, 1925 records remained, and after a 2-phase reading
of abstracts and full texts, 17 studies were included. Propolis, green tea, ginger,
Zataria multiflora, chitosan, garlic, Artemisia, Schinus terebinthifolius Raddi, Uncaria tomentosa, Punica granatum, and Ricinus communis appeared to have similar efficacy and safety when compared with nystatin or miconazole.
Most of the studies presented a high risk of bias.
Conclusions
Certainty in the body of evidence that natural products might be appropriately used
in the treatment of denture stomatitis is low. Well-designed randomized controlled
trials are still needed to evaluate the topic better because there is high heterogeneity
among the studies.
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References
- Denture stomatitis: causes, cures and prevention.Prim Dent J. 2017; 6: 46-51
- Candidiasis: red and white manifestations in the oral cavity.Head Neck Pathol. 2019; 13: 25-32
- Management of denture stomatitis: a narrative review.J Biol Regul Homeost Agents. 2018; 32: 113-116
- Learning the ABC of oral fungal drug resistance.Mol Oral Microbiol. 2015; 30: 425-437
- Drug-drug interactions and adverse drug reactions in polypharmacy among older adults: an integrative review.Rev Lat Am Enfermagem. 2016; 24: e2800
- Natural products for drug discovery in the 21st century: innovations for novel drug discovery.Int J Mol Sci. 2018; 19: 1578
- The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration.BMJ. 2009; 339: 2700
- Updating guidance for reporting systematic reviews: development of the PRISMA 2020 statement.J Clin Epidemiol. 2021; 134: 103-112
- International prospective register of systematic reviews.(Available at:)
- Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline.BMJ. 2020; 368: l6890
- Rayyan: a web and mobile app for systematic reviews.Syst Rev. 2016; 5: 210
- RoB 2: a revised tool for assessing risk of bias in randomised trials.BMJ. 2019; 366: l4898
- ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions.BMJ. 2016; 355: 4919
- Grading quality of evidence and strength of recommendations.BMJ. 2004; 328: 1490
- The effects of three disinfection protocols on Candida spp. denture stomatitis, and biofilm: a parallel group randomized controlled trial.J Prosthet Dent. 2019; 124: 690-698
- Efficacy of 25% aloe cream in treating second degree denture stomatitis.Rev Cuba Estomatol. 2007; 44: 1-7
- Efficacy of Vimang extract in grade I subprosthetic stomatitis.Rev Cuba Estomatol. 2007; 4: 1-7
- The effect of the vinegare plus rose water mouthwash on denture stomatitis candidiasis.J Mazand Univ Med Sci. 2014; 24: 186-195
- Aplicación de un colutorio de aloe en el tratamiento de la stomatitis subprótesis.Arch Med Camaguey. 2003; 7: 560-567
- Clinical assessment of Citrosept dental effectiveness in treatment of Candida-associated denture stomatitis, in patients using removable acrylic dentures.Protet Stomatol. 2018; 68: 200-210
- Avaliação clínica e laboratorial do gel da Uncaria tomentosa (Unha de Gato) sobre candidose oral.Rev Bras Farmacogn. 2009; 19: 423-428
- Tratamento da estomatite protética e o impacto sobre a qualidade de vida, halitose, fluxo e pH salivar: Estudo piloto.Unoesc Ciênc - ACBS. 2013; 4: 101-110
- Effectiveness of topical treatment with Vimang® in patients with denture stomatitis.MEDISAN. 2013; 17: 6031-6038
- Avaliação clínica e laboratorial do tratamento da estomatite protética através de produtos naturais.(Tese de doutorado) Faculdade de Odontologia de Bauru, Universidade de São Paulo, Bauru-SP, Brazil2013: 136
- Comparison of the effect of 2% ginger mouthwash and nystatin mouthwash on denture stomatitis.Int J Adv Biotechnol Res. 2016; 7: 1152-1157
- Miconazole gel compared with Zataria multiflora Boiss gel in the treatment of denture stomatitis.Phytother Res. 2006; 20: 966-969
- In vivo study of antifungal effects of low-molecular-weight chitosan against Candida albicans.J Oral Sci. 2017; 59: 425-430
- Comparison of therapeutic effect of aqueous extract of garlic and nystatin mouthwash in denture stomatitis.Gerodontology. 2012; 29: e680-e684
- Brazilian green propolis compared to miconazole gel in the treatment of Candida-associated denture stomatitis.Evid Based Complement Alternat Med. 2013; 2013: 947980
- Efficacy of Camellia sinensis extract against Candida species in patients with denture stomatitis.Curr Med Mycol. 2018; 4: 15-18
- Comparing the effect of green tea extract with nystatin in the treatment of denture stomatitis.Avicenna J Dent Res. 2015; 7: 5
- Efficacy of propolis on the denture stomatitis treatment in older adults: a multicentric randomized trial.Innov Aging. 2017; 1: 398
- Ricinus communis treatment of denture stomatitis in institutionalised elderly.J Oral Rehabil. 2013; 40: 375-380
- Oral candidiasis treatment with Brazilian ethanol propolis extract.Phytother Res. 2005; 19: 652-654
- Efficacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study.Phytother Res. 2008; 22: 1544-1547
- Evaluation of the effect of Artemisia sieberi mouthwash 1% on denture stomatitis (a preliminary study).Casp J Intern Med. 2010; 1: 47-49
- Clinical and microbiological evaluation of the treatment of denture stomatitis with Schinus terebinthifolius Raddi (Aroeira) tincture.Pesqui Bras Odontoped Clin Integr. 2010; 10: 365-370
- Gel de propóleos en el tratamiento de la estomatitis subprotesis con candidiasis asociada.Multimed. 2006; 10
- Evaluation of different treatment methods against denture stomatitis: a randomized clinical study.Oral Surg Oral Med Oral Pathol Oral Radiol. 2014; 118: 72-77
- Use of Punica granatum as an antifungal agent against candidosis associated with denture stomatitis.Mycoses. 2003; 46: 192-196
- Efectividad de la tintura de propóleos al 10 % en pacientes con estomatitis subprótesis.MEDISAN. 2018; 22: 863-874
- The rational use of drugs and WHO.Dev Dialogue. 1985; : 1-4
Article info
Publication history
Published online: July 08, 2021
Footnotes
Authors declare no conflicts of interest.
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Identification
Copyright
© 2021 by the Editorial Council for the Journal of Prosthetic Dentistry.
