Statement of problem
The reason for variations in peri-implant early crestal bone loss is unclear but may be due to genetic differences among individuals.
The purpose of this nested case control study was to investigate the association of single-nucleotide polymorphisms of interleukin-1, interleukin-6, collagen type I alpha1, and osteocalcin genes to early crestal bone loss around submerged dental implants.
Material and methods
Dental implants were placed in the mandibular posterior region (single edentulous space) of 135 participants selected according to predetermined selection criteria. Bone mineral density measurement by using dual energy X-ray absorptiometry, cone beam computed tomography scans at the baseline and after 6 months, and interleukin-1A-889 A/G (rs1800587), interleukin-1B-511 G/A (rs16944), interleukin-1B+3954 (rs1143634), interleukin-6-572 C/G (rs1800796), collagen type I alpha1 A/C (rs1800012), and osteocalcin C/T (rs1800247) genotyping were performed in all participants. Early crestal bone loss measured around dental implants was used to group participants into clinically significant bone loss (BL)>0.5 mm and clinically nonsignificant bone loss (NBL)≤0.5 mm. Early crestal bone loss was calculated as the mean of the difference of bone levels at the baseline and bone levels after 6 months as measured with cone beam computed tomography scans. The obtained data for basic characteristics, early crestal bone loss, and genotyping were tabulated and compared by using a statistical software program (α=.05).
AA genotype and the A allele frequency of interleukin-1B-511 and GG genotype and the G allele frequency of interleukin-6-572 were significantly higher in BL than in NBL (P<.05). Multiple logistic analysis suggested that interleukin-1B-511 AA/GG+AG and interleukin-6-572 GG/CC+CG genotype expression were significantly associated with early crestal bone loss (AA/GG+AG; P=.014, GG/CC+CG; P=.047) around dental implants. Other risk factors were not significantly different (P>.05).
Of the genes studied, individuals with interleukin-1B-511 AA (rs16944) or interleukin-6-572 GG (rs1800796) genotype had higher susceptibility to early crestal bone loss around dental implants.
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- 3-Year follow up study of early single implant restorations ad modum Brånemark.Int J Periodontics Restorative Dent. 1990; 10: 340-349
- The causes of early implant bone loss: myth or science?.J Periodontol. 2002; 73: 322-333
- Impact of local and systemic factors on the incidence of oral implant failures, up to abutment connection.J Clin Periodontol. 2007; 34: 610-617
- Meta-analysis of the association between common interleukin-1 polymorphisms and dental implant failure.Mol Biol Rep. 2014; 41: 2789-2798
- Evaluation of marginal bone loss around dental implants in cigarette smokers and nonsmokers. A comparative study.J Family Med Prim Care. 2020; 9: 729-734
- Impact of smoking on marginal bone loss.Int J Oral Maxillofac Implants. 2005; 20: 605-609
- Interleukin gene polymorphisms in chronic periodontitis: a case-control study in the Indian population.Arch Oral Biol. 2019; 101: 156-164
- Lack of association between interleukin-1β gene polymorphism (rs16944) and chronic periodontitis: from a case-control studies to an updated meta-analysis.Dis Markers. 2018; 2018: 8287026
- IL1 gene polymorphisms and unsuccessful dental implants.Clin Oral Implants Res. 2012; 23: 1404-1413
- Can genetic factors compromise the success of dental implants? A systematic review and meta-analysis.Genes. 2018; 9: 444
- The relationship between IL-1 gene polymorphism and marginal bone loss around dental implants.J Oral Maxillofac Surg. 2007; 65: 2340-2344
- The interleukin-1 genotype as a severity factor in adult periodontal disease.J Clin Periodontol. 1997; 24: 72-77
- Clinical response to non-surgical periodontal treatment in patients with interleukin-6 and interleukin-10 polymorphisms.Med Oral Patol Oral Cir Bucal. 2017; 22: 446-457
- Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis.J Zhejiang Univ Sci B. 2009; 10: 920-927
- Association between tumor necrosis factor-α promoter -308 A/G, -238 A/G, interleukin-6 -174 G/C and -572 G/C polymorphisms and periodontal disease: a meta-analysis.Mol Biol Rep. 2013; 40: 5191-5203
- A systematic review on the association between genetic predisposition and dental implant biological complications.Clin Oral Implants Res. 2011; 23: 775-788
- Genetic polymorphisms of the interleukin-1 gene and early marginal bone loss around endosseous dental implants.Clin Oral Implants Res. 2003; 14: 423-429
- An exploratory case-control study on the impact of IL-1 gene polymorphisms on early implant failure.Clin Implant Dent Relat Res. 2016; 18: 234-240
- Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women.Arch Oral Biol. 2015; 60: 533-539
- Collagen gene polymorphisms influence fracture risk and bone mass acquisition during childhood and adolescent growth.Bone. 2010; 47: 989-994
- New insights into the biology of osteocalcin.Bone. 2016; 82: 42-49
- Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese.Biochem Biophys Res Commun. 2004; 317: 887-892
- No correlation of five gene polymorphisms with periodontal conditions in a Greek population.J Clin Periodontol. 2006; 33: 765-770
- Association between osteoporosis and polymorphisms of the bone Gla protein, estrogen receptor 1, collagen 1-A1 and calcitonin receptor genes in Turkish postmenopausal women.Gene. 2013; 515: 167-172
- Osteocalcin gene polymorphism in Indonesian men with periodontitis.Int J Appl Pharm. 2020; 12: 18-20
- Patient selection and preparation.in: Branemark P.I. Zarb G.A. Albrektsson T. Tissue integrated prostheses: osseointegration in clinical dentistry. Quintessence Publishing Company, Chicago1985: 199-209
- Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study.Bone. 2008; 42: 271-277
- Dual energy X-ray absorptiometry: pitfalls in measurement and interpretation of bone mineral density.Indian J Endocrinol Metab. 2013; 17: 203-210
- Flapless vs flapped implant insertion in patients with controlled type 2 diabetes subjected to delayed loading: 1-year follow-up results from a randomised controlled trial.Eur J Oral Implantol. 2017; 10: 403-413
- Three-dimensional measurement of bone loss at implants in patients with periodontal disease.J Periodontol. 2011; 82: 689-699
- Accuracy of bone measurements in the vicinity of titanium implants in CBCT data: a comparison of radiological and histological findings in minipigs.BioMed Res Int. 2017; 2017: 3848207
- Protection of the public in situations of prolonged radiation exposure. The application of the Commission's system of radiological protection to controllable radiation exposure due to natural sources and long-lived radioactive residues.Ann ICRP. 1999; 29: 1-109
Published online: July 08, 2021
Supported by “Science & Engineering Research Board” (SERB), a statutory body of Department of Science & Technology, Government of India (file no. EMR/2016//002066).
© 2021 by the Editorial Council for the Journal of Prosthetic Dentistry.