Abstract
Statement of problem
The reason for variations in peri-implant early crestal bone loss is unclear but may
be due to genetic differences among individuals.
Purpose
The purpose of this nested case control study was to investigate the association of
single-nucleotide polymorphisms of interleukin-1, interleukin-6, collagen type I alpha1,
and osteocalcin genes to early crestal bone loss around submerged dental implants.
Material and methods
Dental implants were placed in the mandibular posterior region (single edentulous
space) of 135 participants selected according to predetermined selection criteria.
Bone mineral density measurement by using dual energy X-ray absorptiometry, cone beam
computed tomography scans at the baseline and after 6 months, and interleukin-1A-889
A/G (rs1800587), interleukin-1B-511 G/A (rs16944), interleukin-1B+3954 (rs1143634),
interleukin-6-572 C/G (rs1800796), collagen type I alpha1 A/C (rs1800012), and osteocalcin
C/T (rs1800247) genotyping were performed in all participants. Early crestal bone
loss measured around dental implants was used to group participants into clinically
significant bone loss (BL)>0.5 mm and clinically nonsignificant bone loss (NBL)≤0.5
mm. Early crestal bone loss was calculated as the mean of the difference of bone levels
at the baseline and bone levels after 6 months as measured with cone beam computed
tomography scans. The obtained data for basic characteristics, early crestal bone
loss, and genotyping were tabulated and compared by using a statistical software program
(α=.05).
Results
AA genotype and the A allele frequency of interleukin-1B-511 and GG genotype and the
G allele frequency of interleukin-6-572 were significantly higher in BL than in NBL
(P<.05). Multiple logistic analysis suggested that interleukin-1B-511 AA/GG+AG and interleukin-6-572
GG/CC+CG genotype expression were significantly associated with early crestal bone
loss (AA/GG+AG; P=.014, GG/CC+CG; P=.047) around dental implants. Other risk factors were not significantly different
(P>.05).
Conclusions
Of the genes studied, individuals with interleukin-1B-511 AA (rs16944) or interleukin-6-572
GG (rs1800796) genotype had higher susceptibility to early crestal bone loss around
dental implants.
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Article info
Publication history
Published online: July 08, 2021
Footnotes
Supported by “Science & Engineering Research Board” (SERB), a statutory body of Department of Science & Technology, Government of India (file no. EMR/2016//002066).
Identification
Copyright
© 2021 by the Editorial Council for the Journal of Prosthetic Dentistry.
