Abstract
Statement of problem
Dental implants are susceptible to early failure when placed in patients diagnosed
with type 2 diabetes mellitus. The osteoinductive potential of insulin-like growth
factor-1 (IGF-1) has been widely investigated in animals with type 2 diabetes mellitus,
but studies investigating the osteoinductive potential of IGF-1 around dental implants
in patients diagnosed with type 2 diabetes mellitus are lacking.
Purpose
This randomized controlled trial was conducted to assess the osteogenic efficacy of
poly(lactide-co-glycolide)– (PLGA) encapsulated IGF-1 microspheres around dental implants
placed in patients diagnosed with type 2 diabetes mellitus.
Material and methods
A split-mouth, randomized controlled trial was conducted in 10 participants diagnosed
with type 2 diabetes mellitus and with bilaterally missing mandibular posterior teeth.
The 20 sites were randomly allotted to receive the PLGA encapsulated IGF-1 or placebo
microspheres followed by the placement of Ø3.8×11-mm implants. Osteoblastic activity
was quantitatively assessed with bone scintigraphy scanning on the thirtieth, sixtieth,
and 90th day after implant placement. The Shapiro-Wilks test was used to analyze the
normality of data, followed by the independent t test to compare the experimental and placebo groups. Intragroup comparison was performed
by using repeated-measures ANOVA and the post hoc Bonferroni test (α=.05).
Results
Statistical analysis revealed that the mean osteoblastic activity was higher in the
experimental group which received the PLGA–encapsulated IGF-1 than in the placebo
group at the 30th, 60th, and 90th day after implant placement (P≤.001).
Conclusions
This randomized controlled trial indicated that the PLGA–encapsulated sustained release
of IGF-1 microspheres enhanced the process of osseointegration in patients diagnosed
with type 2 diabetes mellitus until the 90th day after implant placement.
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Article info
Publication history
Published online: July 20, 2021
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2021 by the Editorial Council for the Journal of Prosthetic Dentistry.
