Journal of Prosthetic Dentistry

Effect of sanitizing solutions on cobalt-chromium alloys for dental prostheses: A systematic review of in vitro studies

  • Isabelle C.G. Timbó
    Postgraduate student, Department of Restorative Dentistry, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Federal University of Ceará (FFOE-UFC), Fortaleza, Brazil
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  • Mayara S.C.S. Oliveira
    Postgraduate student, Department of Restorative Dentistry, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Federal University of Ceará (FFOE-UFC), Fortaleza, Brazil
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  • Rômulo R. Regis
    Corresponding author: Dr Rômulo Rocha Regis, Department of Restorative Dentistry, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Alexandre Baraúna St 949, Rodolfo Teófilo, Fortaleza, Ceará, 60430-160, BRAZIL
    Adjunct Professor, Department of Restorative Dentistry, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Federal University of Ceará (FFOE-UFC), Fortaleza, Brazil
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Published:November 07, 2022DOI:


      Statement of problem

      Given the wide use of cobalt-chromium (Co-Cr) alloys, especially for removable partial dentures, and the importance of chemical solutions to complement the cleaning of dental prostheses, safe disinfection products should be identified for the regular decontamination of Co-Cr dental prostheses.


      The purpose of this systematic review of in vitro studies was to determine the effects on the properties of Co-Cr dental alloys of the various chemical agents used to clean dental prostheses.

      Material and methods

      In vitro studies were included based on a literature search conducted in March 2022 in the Medline/PubMed, SCOPUS, Web of Science, Virtual Health Library, and Embase databases. Independent reviewers performed the search, selection, extraction, and analysis of the data. The review was performed based on the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. The quality of the included articles was evaluated by using parameters adapted from the Consolidated Standards of Reporting Trials (CONSORT) guidelines, and the risk of bias analysis was performed based on previous studies.


      Among the 15 included studies, the chemical agents evaluated were alkaline peroxides and hypochlorites, mouthwashes containing cetylpyridinium chloride and chlorhexidine, diluted acids, and enzymes. Some peroxides produced increased ion release, surface roughness, and mass loss of the alloys. The hypochlorites were responsible for the greatest surface corrosion, yielding dark stains, rough regions, and depressions. Acetic and peracetic acids and mouthwashes containing chlorhexidine and cetylpyridinium did not produce significant changes in Co-Cr alloys. Most studies presented moderate risk of bias.


      According to the included studies, mouth rinses containing cetylpyridinium chloride or chlorhexidine and solutions with acetic and peracetic acid could be safely used to chemically sanitize Co-Cr prostheses. Alkaline peroxides should be used with caution, and alkaline hypochlorite solutions should be avoided.
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