Journal of Prosthetic Dentistry
Systematic Review|Articles in Press

Removable prosthetic management for tooth agenesis in the pediatric population: A systematic review of case reports and case series

  • Arya Acca Varghese
    Corresponding author: Dr Arya Acca Varghese, Department of Pediatric and Preventive Dentistry, Vinayaka Mission’s Sankarachariyar Dental College, Vinayaka Missions Research Foundation (Deemed to be University), NH-47, Sankari Main Rd, Ariyanoor, Salem, Tamil Nadu 636308, INDIA
    Assistant Professor, Department of Pediatric and Preventive Dentistry, Vinayaka Mission’s Sankarachariyar Dental College, Vinayaka Missions Research Foundation (Deemed to be University), Salem, Tamil Nadu, India
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  • Arun Mamachan Xavier
    Professor, Department of Pediatric and Preventive Dentistry, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India
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  • Venkitachalam Ramanarayanan
    Reader, Department of Public Health Dentistry, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India
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      Statement of problem

      Dental agenesis is a condition in which the absence of teeth causes debilitating problems, primarily in speech, mastication, and esthetics. The optimal removable prosthetic management for the condition is unclear.


      The purpose of this systematic review was to evaluate the spectrum of removable prosthetic techniques with regard to the type of edentulism and to provide clinical guidance for practicing dentists.

      Material and methods

      An electronic and manual search was conducted in the PubMed, Scopus, and Google Scholar databases. Publications of case reports and series written in English without data restrictions that reported on removable prosthodontic management of patients with oligodontia, hypodontia, or anodontia were included.


      A total of 59 articles comprising 83 case reports were analyzed. In patients with anodontia, the most common treatment option was an acrylic resin complete denture. Hypodontia and oligodontia were commonly managed by using either a partial denture or overdenture. Irreversible hydrocolloid or alginate was the most accepted material for the preliminary impressions and elastomeric materials for definitive impressions. The tooth arrangements were modified to simulate natural dentition and improve esthetics. Modifications of conventional acrylic resin dentures have been proposed for improved denture adaptation. Good retention is essential to the long-term success of prosthetic treatment and may be achieved with a denture reline or with retention clasps. The active growth of the patients means constant maintenance, including denture renewals or repairs, emphasizing the need for long-term follow-up care.


      Prosthodontic rehabilitation at an early age has been shown to significantly impact the overall quality of life for a child with tooth agenesis.
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        • Zengin A.Z.
        • Sumer A.P.
        • Karaarslan E.
        Impacted primary tooth and tooth agenesis: a case report of monozygotic twins.
        Eur J Dent. 2008; 2: 299-302
        • De Coster P.J.
        • Marks L.A.
        • Martens L.C.
        • Huysseune A.
        Dental agenesis: genetic and clinical perspectives.
        J Oral Pathol Med. 2009; 38: 1-7
        • Thalji G.N.
        • Cooper L.F.
        The role of complete overdentures in esthetic rehabilitation of the adolescent oligodontia patient. A case report.
        J Esthet Restor Dent. 2010; 22: 213-221
        • Shimizu T.
        • Maeda T.
        Prevalence and genetic basis of tooth agenesis.
        Jpn Dent Sci Rev. 2009; 45: 52-58
        • Steward R.E.
        Pediatric Dentistry: Scientific Foundations and Clinical Practice. Mosby, St. Louis, Missouri1982: 91
        • Derbanne M.A.
        • Sitbon M.C.
        • Landru M.M.
        • Naveau A.J.
        Early prosthetic treatment in children with ectodermal dysplasia.
        Eur Arch Paediatr Dent. 2010; 11: 301-305
        • Vieira K.A.
        • Teixeira M.S.
        • Guirado C.G.
        • Gaviäo M.B.
        Prosthodontic treatment of hypohidrotic ectodermal dysplasia with complete anodontia: case report.
        Quintessence Int. 2007; 38: 75-80
        • Bani M.
        • Tezkirecioglu A.M.
        • Akal N.
        • Tuzuner T.
        Ectodermal dysplasia with anodontia: a report of two cases.
        Eur J Dent. 2010; 4: 215-222
        • Till M.J.
        • Marques A.P.
        Ectodermal dysplasia: treatment considerations and case reports.
        Northwest Dent. 1992; 71: 25-28
        • Khazaie R.
        • Berroeta E.M.
        • Borrero C.
        • Torbati A.
        • Chee W.
        Five-year follow-up treatment of an ectodermal dysplasia patient with maxillary anterior composites and mandibular denture: a clinical report.
        J Prosthodont. 2010; 19: 294-298
        • Bhargava A.
        • Sharma A.
        • Popli S.
        • Bhargava R.
        Prosthodontic management of a child with ectodermal dysplasia: a case report.
        J Indian Prosthodont Soc. 2010; 10: 137-140
        • Hekmatfar S.
        • Jafari K.
        • Meshki R.
        • Badakhsh S.
        Dental management of ectodermal dysplasia: two clinical case reports.
        J Dent Res Dent Clin Dent Prospects. 2012; 6: 108-112
        • Manuja N.
        • Passi S.
        • Pandit I.K.
        • Singh N.
        Management of a case of ectodermal dysplasia: a multidisciplinary approach.
        J Dent Child. 2011; 78: 107-110
        • Zhang S.
        LibGuides: APA 7th style: Critical appraisal tools.
        (Available at:)
        • Shekhar G.
        • RamaRaju A.
        • Rao C.
        • Sarada S.
        Prosthetic rehabilitation for a patient with hypohidrotic ectodermal dysplasia: a clinical case.
        Braz J Oral Sci. 2010; 9: 63-66
        • Grewal P.S.
        • Gupta K.P.
        Prosthetic rehabilitation of a young patient with Hypophosphatasia–a review and case report.
        Contemp Clin Dent. 2012; 3: 74-77
        • Jain N.
        • Naitam D.
        • Wadkar A.
        • Nemane A.
        • Katoch S.
        • Dewangan A.
        Prosthodontic rehabilitation of hereditary ectodermal dysplasia in an 11-year-old patient with flexible denture: a case report.
        Case Rep Dent. 2012; 2012: 489769
        • Shigli A.
        • Sarkar P.A.
        Prosthodontic management of patients with Christ–Siemens–Touraine syndrome.
        Case Rep. 2012; 2012bcr1120115226
        • Yadav N.
        • Kumar D.
        • Legha V.S.
        • Kumar K.A.
        A simplified approach for prosthodontic management of syndromic oligodontia.
        Med J Armed Forces India. 2015; 71: S466
        • Swain J.R.
        • Mohanty S.
        • Acharya S.
        • Singh B.
        Ectodermal dysplasia: a case report of aesthetic and functional rehabilitation.
        Indian J Forensic Med Toxicol. 2020; 14: 8696-8699
        • Suvarna G.S.
        • Nadiger R.K.
        • Guttal S.S.
        • Shetty O.
        Prosthetic rehabilitation of hypophosphatasia with precision attachment retained unconventional partial denture: a case report.
        J Clin Diagn Res. 2014; 8: ZD08
        • Bhalla G.
        • Agrawal K.K.
        • Chand P.
        • et al.
        Effect of complete dentures on craniofacial growth of an ectodermal dysplasia patient: a clinical report.
        J Prosthodont. 2013; 22: 495-500
        • Ladda R.
        • Gangadhar S.A.
        • Kasat V.O.
        • Bhandari A.J.
        Prosthodontic management of hypohidrotic ectodermal dysplasia with anodontia: a case report in pediatric patient and review of literature.
        Ann Med Health Sci Res. 2013; 3: 277-281
        • Nandini Y.
        Prosthodontic management of a patient with ectodermal dysplasia.
        J Coll Physicians Surg-Pak. 2013; 23: 899-901
        • Singh T.
        • Singh R.
        • Singh G.P.
        • Singh J.P.
        Hypohidrotic ectodermal dysplasia: a felicitous approach to esthetic and prosthetic management.
        Int J Clin Pediatr Dent. 2013; 6: 140-145
        • Trivedi B.D.
        • Bhatia R.
        Complete and removable partial prosthesis for a child with hypohidrotic ectodermal dysplasia.
        Int J Clin Pediatr Dent. 2013; 6: 71-74
        • Ephraim R.
        • Rajamani T.
        • Feroz T.M.
        • Abraham S.
        Agenesis of multiple primary and permanent teeth unilaterally and its possible management.
        J Int Oral Health. 2015; 7: 68-70
        • Rathee M.
        • Malik P.
        • Dua M.
        • Yadav V.
        Early functional, esthetic, and psychological rehabilitation of preschool child with non-syndromic oligodontia and anodontia in mixed dentition stage through conservative systematic approach: a case report with 5-year follow-up.
        Contemp Clin Dent. 2016; 7: 232-235
        • Virk P.K.
        • Sharma U.
        Nonsyndromic oligodontia involving the maxillary arch: a rare case report.
        J South Asian Assoc Pediatr Dent. 2021; 4: 54-57
        • Thulasingam C.
        • Akshayalingam M.
        • vashisht P.
        Early prosthodontic intervention in a child patient of hypohidrotic ectodermal dysplasia.
        SRM J Res Dent Sci. 2013; 4: 73-77
        • Mathian V.M.
        • Gawthaman M.
        • Karunakaran R.
        • Vinodh S.
        • Manikandan S.
        • Sundaram A.M.
        Non-syndromic oligodontia in siblings: a rare case report.
        J Pharm Bioallied Sci. 2014; 6: S200-203
        • Ramakrishnan M.
        • Gandeeban K.
        Nonsyndromic oligodontia associated with submerged primary molars: Clinical features and management protocols.
        SRM J Res Dent Sci. 2014; 5: 199-202
        • Rathee M.
        • Mahesh G.
        • Arun K.
        • Richa M.
        • Renu K.
        Rehabilitation of non-syndromic oligodontia of primary and permanent dentition in young patient-A rare case report.
        Interdiscipl Med Dent Sci. 2014; 2: 1-4
        • Bala S.
        • Nikhil M.
        • Chugh A.
        • Narwal A.
        Prosthetic rehabilitation of a child suffering from hypohidrotic ectodermal dysplasia with complete anodontia.
        Int J Clin Pediatr Dent. 2012; 5: 148-150
        • Bharadwaj B.
        Ectodermal dysplasia in a 6 years old: a clinical challenge.
        World J Dent. 2015; 6: 58-60
        • Retnakumari N.
        • Varghese M.
        • Kannan V.P.
        Christ Siemens Touraine syndrome: a rare case report.
        J Indian Soc Pedod Prev Dent. 2016; 34: 185-188
        • Vasanthakumari A.
        • Venkataraghavan K.
        • Nivethitha D.K.
        The management of patient with oligodontia associated with attention deficit hyperactive disorder – a rare case report.
        Int J Clin Dent Sci. 2012; 3: 49-54
        • Montanari M.
        • Callea M.
        • Battelli F.
        • Piana G.
        Oral rehabilitation of children with ectodermal dysplasia.
        Case Rep. 2012; 2012bcr0120125652
        • Cagetti M.G.
        • Camoni N.
        • Cetraro F.
        • Scanferla M.
        • Moretti G.M.
        Special-needs patients in pediatric dentistry: Progeroid syndrome. A case of dental management and oral rehabilitation.
        Pediatr Rep. 2019; 11: 7951
        • Dalben G.D.
        • Danelon L.B.
        • Carrara C.F.
        Prosthetic rehabilitation of a child with Rapp-Hodgkin syndrome.
        J Dent Child. 2012; 79: 115-119
        • Gonçalves T.M.
        • Gonçalves L.M.
        • Sabino-Bezerra J.R.
        • Santos-Silva A.R.
        • Silva W.J.
        • Garcia R.C.
        Multidisciplinary therapy of extensive oligodontia: a case report.
        Braz Dent J. 2013; 24: 174-178
        • Starling C.R.
        • Souza C.M.
        • Ferreira R.F.
        • Bittencourt M.A.
        Early treatment of non-syndromic oligodontia: a clinical case report.
        BioSci J. 2017; 33: 232-237
        • Pinto M.M.
        • da Silva L.B.
        • Alfaya T.A.
        • et al.
        Oral rehabilitation in a pediatric patient with hypohidrotic ectodermal dysplasia.
        Clin Exp Med Lett. 2012; 53: 149-152
        • Vilanova L.S.R.
        • Sánchez-Ayala A.
        • Ribeiro G.R.
        • Campos C.H.
        • Farias-Neto A.
        Conventional complete denture in patients with ectodermal dysplasia.
        Case Rep Dent. 2015; 2015: 714963
        • Mira P.C.
        • Arid J.
        • Paula-Silva F.W.G.
        • de Queiroz A.M.
        • de Carvalho F.K.
        • Pagnano V.O.
        Oral rehabilitation in a patient with Jeune syndrome presenting with multiple teeth agenesis.
        Spec Care Dent. 2020; 40: 493-497
        • Taghdisi K.A.
        • Hesarkhani A.
        • Fotovat F.
        • Abdolkarimpour Z.
        • Allahbakhshi H.
        Overlay removable partial dentures for a 10-year old child with oligodontia and posterior open bite occlusion: a clinical report.
        J Kerman Univ Med Sci. 2019; 26: 169-176
        • Atri F.
        • Azizi S.
        • Hatampor S.
        Removable prosthetic treatment of an ectodermal dysplasia patient: a case report.
        J Craniomax Res. 2020; 7: 34-39
        • Nguyen J.P.
        • Chandy T.S.
        • Sparks J.
        • Driscoll C.F.
        • Masri R.
        Leveraging digital technology for treatment of young patients with congenital conditions: a clinical report.
        J Prosthodont. 2021; 30: 150-157
        • Levy-Bercowski D.
        • Abreu A.
        • Parker C.
        • Riggs B.
        • Rockman R.
        Immediate vacuum formed overdenture for a pediatric patient with ectodermal dysplasia.
        J Dent Child. 2018; 85: 139-142
        • Tozar K.N.
        • Almaz M.E.
        A treatment of a pediatric patient with isolated oligodontia: case report.
        ADYÜ Sağlık Bilim Derg. 2020; 6: 395-400
        • Bayram M.
        • Yildirim M.
        • Seymen F.
        Clinical and oral findings of a patient with Simpson-Golabi-Behmel syndrome.
        Eur Arch Paediatr Dent. 2015; 16: 63-66
        • Bildik T.
        • Ozbaran B.
        • Kose S.
        • et al.
        Hypohidrotic ectodermal dysplasia: a multidisciplinary approach.
        Int J Psychiatry Med. 2012; 44: 225-240
        • Maatouk F.
        • Afia I.B.
        • Masmoudi F.
        • Laribi W.
        • Ghedira H.
        Prosthodontic management of children with hypohidrotic ectodermal dysplasia: case reports and a review of the literature.
        J Dent. 2015; 3: 34-40
        • Maroulakos G.
        • Artopoulou I.I.
        • Angelopoulou M.V.
        • Emmanouil D.
        Removable partial dentures vs overdentures in children with ectodermal dysplasia: two case reports.
        Eur Arch Paediatr Dent. 2016; 17: 205-210
        • Dali M.
        • Shrestha S.
        • Rajbanshi L.K.
        Esthetic rehabilitation of familial hypodontia: a case report.
        BJHS. 2016; 1: 72-75
        • Dali M.
        • Singh R.
        • Naulakha D.
        Idiopathic non-syndromic tooth agenesis: a report of rare three.
        J Interdiscip Dent. 2012; 2: 190-194
        • Waldron J.M.
        • McNamara C.
        • Hewson A.R.
        • McNamara C.M.
        Axenfeld-Rieger syndrome (ARS): a review and case report.
        Spec Care Dent. 2010; 30: 218-222
        • Ahmed B.
        Prosthodontic rehabilitation of Papillon Lefevre Syndrome.
        J Coll Phys Surg Pak. 2014; 24: S132-S134
        • Ahmed R.
        • Rayhanb M.A.
        • Khan A.
        • Rahman M.M.
        Prosthetic rehabilitation of oligodontia in a child: a case report.
        Updat Dent Coll J. 2014; 4: 38-43
        • Tong H.J.
        • Tahmassebi J.F.
        Management of a child with severe hypodontia in the mixed dentition stage of development.
        Eur Arch Paediatr Dent. 2014; 15: 449-454
        • Kim K.
        • Noh K.
        • Paek J.
        • Kwon K.R.
        • Pae A.
        Prosthetic management of a growing patient with Russell-Silver syndrome: a clinical report.
        J Adv Prosthodont. 2015; 7: 406-410
        • Błaszczak J.
        • Skawinska A.
        • Mielnik-Blaszczak M.
        Ectodermal dysplasia with anodontia – case report.
        J Stoma. 2016; 69: 374-378
        • Hassona Y.
        • Rajab L.
        • Taimeh D.
        • Scully C.
        Sanjad-Sakati Syndrome: oral health care.
        Med Princ Pract Int J Kuwait Univ Health Sci Cent. 2018; 27: 293-296
        • Omondi B.I.
        • Chepkwony F.
        • Ariemba R.M.
        • Miyogo J.O.
        • Opinya G.N.
        Prosthodontic rehabilitation of a child with ectodermal dysplasia: a preliminary report.
        Int J Prosthodont. 2019; 32: 107-109
        • Chen Y.
        • Zhou F.
        • Peng Y.
        • Chen L.
        • Wang Y.
        Non-syndromic occurrence of true generalized microdontia with hypodontia: a case report.
        Medicine (Baltimore). 2019; 98e16283
        • Benz K.
        • Kozmacs C.
        • Piwowarczyk A.
        • Jackowski J.
        Prosthetic rehabilitation for a patient treated for embryonal rhabdomyosarcoma.
        J Prosthet Dent. 2018; 120: 299-302