Abstract
Statement of problem
Despite the importance of Candida spp. on the etiology of denture stomatitis (DS), information on the role of the bacterial
component is still scarce.
Purpose
The purpose of this systematic review was to evaluate whether the counts of Staphylococcus aureus and Streptococcus mutans were changed in complete denture wearers diagnosed with Candida-associated DS.
Material and methods
The literature search was performed in 8 databases and by hand searching. The risk
of bias was assessed according to the Newcastle-Ottawa qualifier. Meta-analyses were
performed considering the microorganism evaluated (S. aureus or S. mutans) and the collection area (mucosa or dentures). The certainty of evidence was assessed
according to the grading of recommendations assessment, development and evaluations
(GRADE) criteria.
Results
Participants with DS presented higher counts of S. aureus in the mucosa compared with those from the control group (OR, 3.16 [1.62, 6.15];
P<.001). No significant difference between the groups was observed for samples collected
from dentures (OR, 0.73 [0.50, 1.07]; P=.110). Conversely, participants without DS presented higher counts of S. mutans both in the mucosa (OR, 0.19 [0.06, 0.63]; P=.006) and dentures (OR, 0.64 [0.41, 1.0]; P=.050).
Conclusions
Microbial counts in participants with DS changed as a function of the type of microorganism
and collection site. The certainty of evidence ranged from very low to low. The findings
reinforce the fact that bacteria also play a relevant role in DS and should be more
extensively studied. Such information may be useful to guide further therapies to
prevent or control DS.
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Article info
Publication history
Published online: April 18, 2023
Publication stage
In Press Corrected ProofFootnotes
Funding: Supported by CAPES-Brazil (Finance code 001) and CAPES-PrInt (Process 88887.371644/2019-00).
Identification
Copyright
© 2023 by the Editorial Council for The Journal of Prosthetic Dentistry.
