Statement of problem
Despite the importance of Candida spp. on the etiology of denture stomatitis (DS), information on the role of the bacterial component is still scarce.
The purpose of this systematic review was to evaluate whether the counts of Staphylococcus aureus and Streptococcus mutans were changed in complete denture wearers diagnosed with Candida-associated DS.
Material and methods
The literature search was performed in 8 databases and by hand searching. The risk of bias was assessed according to the Newcastle-Ottawa qualifier. Meta-analyses were performed considering the microorganism evaluated (S. aureus or S. mutans) and the collection area (mucosa or dentures). The certainty of evidence was assessed according to the grading of recommendations assessment, development and evaluations (GRADE) criteria.
Participants with DS presented higher counts of S. aureus in the mucosa compared with those from the control group (OR, 3.16 [1.62, 6.15]; P<.001). No significant difference between the groups was observed for samples collected from dentures (OR, 0.73 [0.50, 1.07]; P=.110). Conversely, participants without DS presented higher counts of S. mutans both in the mucosa (OR, 0.19 [0.06, 0.63]; P=.006) and dentures (OR, 0.64 [0.41, 1.0]; P=.050).
Microbial counts in participants with DS changed as a function of the type of microorganism and collection site. The certainty of evidence ranged from very low to low. The findings reinforce the fact that bacteria also play a relevant role in DS and should be more extensively studied. Such information may be useful to guide further therapies to prevent or control DS.
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- Epidemiology and etiology of denture stomatitis.J Prosthodont. 2011; 20: 251-260
- Risk factors for denture-related oral mucosal lesions in a geriatric population.J Prosthet Dent. 2014; 111: 273-279
- Association between denture stomatitis, Candida species and diabetic status.J Biol Regul Homeost Agents. 2019; 33: 35-41
- Microbial changes in biofilms on composite resins with different surface roughness: an in vitro study with a multispecies biofilm model.J Prosthet Dent. 2019; 122: 493.e1-493.e8
- Effects of material properties on bacterial adhesion and biofilm formation.J Dent Res. 2015; 94: 1027-1034
- Denture stomatitis - a review of the aetiology, diagnosis and management.Aust Dent J. 1992; 37: 107-114
- The effect of overnight storage conditions on complete denture colonization by Candida albicans and dimensional stability: a systematic review.J Prosthet Dent. 2020; 124: 176-182
- Denture stomatitis: a role for Candida biofilms.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004; 98: 53-59
- Oral candidiasis: a disease of opportunity.J Fungi (Basel). 2020; 6: 15
- Multispecies communities: interspecies interactions influence growth on saliva as sole nutritional source.Int J Oral Sci. 2011; 3: 49-54
- Dental biofilm: ecological interactions in health and disease.J Clin Periodontol. 2017; 44: S12-S22
- Antibiotic use and microbiome function.Biochem Pharmacol. 2017; 134: 114-126
- Role of the microbiota in immunity and inflammation.Cell. 2014; 157: 121-141
- Candida albicans biofilms and polymicrobial interactions.Crit Rev Microbiol. 2021; 47: 91-111
- Analysis of transcription of the Staphylococcus aureus aerobic class Ib and anaerobic class III ribonucleotide reductase genes in response to oxygen.J Bacteriol. 2001; 183: 7260-7272
- Staphylococcus aureus in the oral cavity: a three-year retrospective analysis of clinical laboratory data.Br Dent J. 2003; 195: 701-703
- Do the oral Staphylococcus aureus strains from denture wearers have a greater pathogenicity potential?.J Oral Microbiol. 2018; 11: 1536193
- Microbial interactions and differential protein expression in Staphylococcus aureus-Candida albicans dual-species biofilms.FEMS Immunol Med Microbiol. 2010; 59: 493-503
- Candida albicans and Staphylococcus aureus form polymicrobial biofilms: effects on antimicrobial resistance.Antimicrob Agents Chemother. 2009; 53: 3914-3922
- Staphylococcus aureus adherence to Candida albicans hyphae is mediated by the hyphal adhesin Als3p.Microbiology. 2012; 158: 2975-2986
- Candida albicans augments Staphylococcus aureus virulence by engaging the Staphylococcal agr quorum sensing system.mBio. 2019; 10: e00910-e00919
- Oral Microbiology. 5th ed. Churchill Livingstone, United Kingdom2009: 15-16
- Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo.Infect Immun. 2014; 82: 1968-1981
- Candida albicans stimulates Streptococcus mutans microcolony development via cross-kingdom biofilm-derived metabolites.Sci Rep. 2017; 7: 41332
- Dual-species biofilms of Streptococcus mutans and Candida albicans exhibit more biomass and are mutually beneficial compared with single-species biofilms.J Oral Microbiol. 2019; 11: 1581520
- Alteration of the coadherence of Candida albicans with oral bacteria by dietary sugars.Oral Microbiol Immunol. 2001; 16: 279-283
- Candida albicans, Staphylococcus aureus and Streptococcus mutans colonization in patients wearing dental prosthesis.Med Oral Patol Oral Cir Bucal. 2005; 58: 1429-1436
- Streptococcus mutans competence-stimulating peptide inhibits Candida albicans hypha formation.Eukaryot Cell. 2009; 8: 1658-1664
- Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition.Org Biomol Chem. 2010; 8: 5486-5489
- Streptococcus mutans can modulate biofilm formation and attenuate the virulence of Candida albicans.PLoS One. 2016; 11e0150457
- The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.BMJ. 2021; 372: n71
- The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of nonrandomised Studies in Meta-Analyses, Ottawa Health Research Institute; Ottawa, Canada.(Available at:)https://www.ohri.ca/programs/clinical_epidemiology/oxford.aspDate accessed: April 14, 2023
- Cochrane Handbook for Systematic Reviews of Interventions version 6.3.(updated February 2022) The Cochrane Collaboration, Oxford2022 (Available at:)www.training.cochrane.org/handbookDate accessed: April 14, 2023
- How to GRADE the Quality of the Evidence.Cochrane Consumers and Communication Group, Melbourne, Australia2016: 23-25
- The effect of Octapinol, a substance with low antibacterial activity, on denture plaque and denture-induced stomatitis.Clin Prev Dent. 1984; 6: 23-27
- Molecular community profiling of the bacterial microbiota associated with denture-related stomatitis.Sci Rep. 2019; 9: 1-13
- Mykologische Diagnostik und antimykotische Therapie bei Stomatitis prothetica [Mycological diagnosis and antimycotic therapy in denture stomatitis].Zahn Mund Kieferheilkd Zentralbl. 1986; 74 ([in German]): 123-130
- Clinical trial for evaluation of Ricinus communis and sodium hypochlorite as denture cleanser.J Appl Oral Sci. 2017; 25: 324-334
- Povezanost Candide albicans in patogenih bakterija u etiologiji palatitis prothetica [Interaction of Candida albicans and pathogenic bacteria in the etiology of denture stomatitis].Acta Stomatol Croat. 1986; 20 ([in Croatian]): 225-232
- Estomatite por prótese total--presença de bactérias e fungos [Denture stomatitis--presence of bacteria and yeasts].Arq Cent Estud Curso Odontol. 1990; 27 ([in Portuguese]): 9-15
- The Denture-Associated Oral Microbiome in Health and Stomatitis.mSphere. 2016; 1: e00215-e00216
- Existence of Candida albicans and microorganisms in denture stomatitis patients.J Oral Rehabil. 1997; 24: 788-790
- The prevalence of Staphylococcus aureus, Enterobacteriaceaespecies, and Candida species and their relation to oral mucosal lesions in a group of 79-year-olds in Göteborg.Acta Odontol Scand. 1995; 53: 49-54
- Bacterial involvement in denture-induced stomatitis.J Dent Res. 1988; 67: 1246-1250
- The predominant microflora of the palatal mucosa in an elderly island population.Acta Odontol Scand. 1992; 50: 163-169
- Biofilm microbial communities of denture stomatitis.Oral Microbiol Immunol. 2008; 23: 419-424
- Microbial colonization and their relation with potential cofactors in patients with denture stomatitis.J Contemp Dent Pract. 2012; 13: 456-459
- Opportunistic microorganisms in individuals with lesions of denture stomatitis.Diagn Microbiol Infect Dis. 2013; 76: 419-424
- Dentures are a reservoir for respiratory pathogens.J Prosthodont. 2016; 25: 99-104
Published online: April 18, 2023
Publication stageIn Press Corrected Proof
Funding: Supported by CAPES-Brazil (Finance code 001) and CAPES-PrInt (Process 88887.371644/2019-00).
© 2023 by the Editorial Council for The Journal of Prosthetic Dentistry.